Session I: Read-across and data completeness
The objective is to broaden awareness of data completeness while fostering best practices within the EU-US communities. The participants will discuss the data requirements and gaps for read-across applicability with nanomaterials, the concepts of data completeness from the recent nanoWG series of papers and the use of current templates to guide data collection. Zeta potential will be used as a test case of the challenges involved with a focus on data taken for the NM-series and related materials.
Read-across means there are data gaps, and everyone recognizes that graphical interpolation, computer simulations, ab initio modelling and many other tools would have a value if validated. Read across applies to a smaller sub-set that can have a narrower ontology and act as a test case for data completeness, data readiness and definitions (nano form (EU) or nanoscale form (US)). The concept involves chemical grouping for a specific purpose, which might be a useful wayside station until there is a more complete system.
In this context, having shared or federated databases become essential. The best data management strategies need to be addressed, that potential users and developers can refer to when suggesting improvements or offering commentary. In particular for zeta potential, colleagues from a broad spectrum of scientific backgrounds and disciplines are generating data for a measurement susceptible to nuanced interpretations.
Framing nanoEHS Data - Fred Klaessig
The participants will become aware of:
Isoelectric point is better than zeta potential for identifying coatings on particles;
The current templates does not request pH for zeta potential (nor for solubility) and requests dielectric constants when the measurement taken is conductivity;
Solubility is a challenge and more immediate to nanoEHS than zeta potential, but the SCCS members are not practiced nor do they offer applicants with guidelines;
Klimisch scores have a regulatory value, but are a ham-fisted approach to scientific data quality;
There needs to be a minimum ontology for coated particles that drives the testing and metadata; and
Biologists should be given more guidance on the purpose, tools and interpretations of zeta potential and other p-chem parameters.