b) How to group (e.g. silica-coated ZnO nanoparticles) for environmental dispersal, toxicity, and protein corona formation:
- zeta potential;
Not unless we can show that the underlying core does not affect the resulting silica shell in terms of its surface characteristics (silanol groups, bond strain, defects, dissolution rate etc, - there is data that shows that adding a fluorescence group alters dramatically the silica structure and dissolution - Mahon, Chem Comm, 2012,48, 7970-7972 ).
Iseult is correct. The question becomes the purpose of the read across class. If the purpose is dissolution, then one needs to demonstrate if the silica shell delays/inhibits/retards dissolution within the time period of the test. Secondarily, the silica shell may be stable for the test time period, but eventually dissolve away to the point that it is not a chronic source of toxicity. At present, the silica shell is often not included in the description of the particle, which means the effects in Iseult and my answers are not fully considered.